Hypochlorous Acid: A Review
J Oral Maxillofac Surg 78 2020
The surgeon needs to have an inexpensive, available, nontoxic, and practical disinfectant that is effective in sanitizing against the COVID-19 (Coronavirus Disease 2019) virus. The purpose of this article was to review the evidence for using hypochlorous acid in the office setting on a daily basis.
The method used to assemble recommendations was a review of the literature including evidence for this solution when used in different locations and industries other than the oral-maxillofacial clinic facility. The results indicate that this material can be used with a high predictability for disinfecting against the COVID-19 (Coronavirus Disease 2019) virus.
A centralised, automated dental hospital water quality and biofilm management system using neutral Ecasol maintains dental unit waterline output at better than potable quality: A 2-year longitudinal study.
Antiviral activity of Ecasol against feline calicivirus, a surrogate of human norovirus.
Evaluation of vaporized hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study.
A preliminary assessment of Bacillus anthracis spore inactivation using an electrochemically activated solution (ECASOL).
Efficacy of super-oxidized water fogging in environmental decontamination
Comparative Antimicrobial Activities of Aerosolized Sodium Hypochlorite, Chlorine Dioxide, and Electrochemically Activated Solutions Evaluated Using a Novel Standardized Assay
Application of neutral electrolyzed water to disinfection of alginate impression
The Antibacterial Efficacy and In Vivo Toxicity of Sodium Hypochlorite and Electrolyzed Oxidizing (EO) Water-Based Endodontic Irrigating Solutions
Lack of cytotoxicity by Trustwater Ecasol used to maintain good quality dental unit waterline output water in keratinocyte monolayer and reconstituted human oral epithelial tissue models
Journal of Dentistry, Volume 38, Issue 11
Abstract: We previously showed that residual treatment of dental chair unit (DCU) supply water using the electrochemically-activated solution Trustwater Ecasol (2.5 ppm) provided an effective long-term solution to the problem of dental unit waterline (DUWL) biofilm resulting in DUWL output water quality consistently superior to potable water.
Objectives: To investigate the cytoxicity of Ecasol using cultured keratinocyte monolayers and reconstituted human oral epithelial (RHE) tissue and to extend the study of Ecasol’s effectiveness in maintaining the microbiological quality of DUWL output water. Methods: TR146 human keratinocyte monolayers and RHE tissues were exposed to Ecasol (2.5–100 ppm) for 1 h periods after removal of growth medium and washing with phosphate- buffered saline (PBS). Experiments were repeated using Ecasol that had been exposed for 30 min to 1–2 mg/mL bovine serum albumin (BSA), equivalent to protein concentrations in saliva. To quantitatively determine cytotoxic effects on monolayers following Ecasol exposure, the Alamar Blue proliferation assay (assesses cell viability) and the Trypan Blue exclusion assay (assesses plasma membrane integrity), were used. Cytotoxicity effects on RHE tissues were assessed by the Alamar Blue assay and by histopathology.Results: Ecasol at >5.0 ppm resulted in significant (P < 0.001) cytotoxicity to keratinocyte monolayers following a 1 h exposure. These effects, however, were completely negated by BSA pretreatment of Ecasol. No cytotoxicity was observed in the more complex RHE tissue at any of the Ecasol concentrations tested. In a 60-week study of 10 DCUs, tested weekly, the average density of aerobic heterotrophic bacteria in Ecasol-treated (2.5 ppm) DCU supply water was <1 cfu/mL and in DUWL output water was 6.5 cfu/mL.
Conclusions: Ecasol present as a residual disinfectant in DUWL output water is very unlikely to have adverse effects on human oral tissues at levels effective in maintaining DUWL output water quality at better than potable standard water quality.
Viability and Effects on Bacterial Proteins by Oral Rinses with Hypochlorous Acid as Active Ingredient
Evaluation of Liquid- and Fog-Based Application of Sterilox Hypochlorous Acid Solution for Surface Inactivation of Human Norovirus
Application of neutral electrolyzed water to disinfection of alginate impression
Effectiveness of Hypochlorous Acid to Reduce the Biofilms on Titanium Alloy Surfaces in Vitro
Bactericidal Effect of Strong Acid Electrolyzed Water against Flow Enterococcus faecalis Biofilms
Dentaqua is passionate about protecting people from microbiological infection. We develop and manufacture the world’s most advanced devices for the in-situ production of hypochlorous acid plus short-lived reactive oxygen species. Dentaqua’s unique disinfectant is highly effective at very low concentrations and contact times, yet is a non-toxic and eco-friendly solution. With the only precursors being water and a proprietary salt additive, at the touch of a button, our technology produces all of your general disinfectant, environmental decontamination and water-related disinfection needs.
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